EFEK TERAPI KOMBINASI METFORMIN – OKSIGEN HIPERBARIK PADA PASIEN DIABETES MELLITUS TIPE 2 SUB JUDUL : PENINGKATAN KADAR ENDOTHELIAL NITRIC OXIDE SYNTHASE (eNOS) DAN PENURUNAN KADAR GLUKOSA DARAH

EFEK TERAPI KOMBINASI METFORMIN – OKSIGEN HIPERBARIK
PADA PASIEN DIABETES MELLITUS TIPE 2 SUB JUDUL :
PENINGKATAN KADAR ENDOTHELIAL NITRIC OXIDE SYNTHASE
(eNOS) DAN PENURUNAN KADAR GLUKOSA DARAH
Abstrak :
Metformin is the first line drug of type 2 diabetes patients. Its improves Insulin sensitivity as mechanism of
action via activation of cyclic-adenomonophosphat dependent protein kinase (AMPK), reduces hepatic
glucose product by reducing gluconeogenesis, and increases endothelial Nitric Oxide Synthase (eNOS).
Chronic hyperglycemia induces Nitric Oxide (NO) dysfunction, where as, NO is important vasodilator in
human body. Due to of NO dysfunction, cells become hypoxia to ischemic then cell apoptotic, included cells
beta pancreatic. The aim of this study to find new management in optimalisation of Metformin therapy in
patients with type 2 diabetes, especially in the improvement of blood glucose into ’normoglycemia’
and eNOS, the important indicator for vascular condition. Hyperbaric oxygen (HBO), 2.4 ATA, which is
given 3x30 minutes with 5 minutes intervals for 10 times within 10 days continually, reduces directly blood
glucose, improves NO function and inhibits cytokines released. Therefore, HBO therapy is considered as
an adjuvant treatment in type 2 DM beside Metformin.Methods : This study was conducted by a clinical pre
and post experiment without control. The ten men’s correspondents in the study were chosed randomly.
Blood glucose and eNOS concentration are used as the parameters in this study. They were examined
before, during and after the combination treatment of Metformin and HBO were given. All parameters
were statistically analyzed by paired t-test.Result : The concentration of eNOS were increased significantly
and also with the blood glucose condition, it reduced significantly after the combination treatment of
Metformin and HBO.Conclusion : HBO therapy works synergism with Metformin in diabetes type2
therapy, especially by improving Metformin therapy in reduced blood glucose and raised eNOS. It is a new
hope to prevent micro and macro angiopathy’s complication in patient with chronic hyperglycemia
caused by type 2 diabetes

sumber:

Penulis : Bernadette Dian Novita Dewi, dr.

Fakultas : Kedokteran

Program Studi : IKD-Farmakologi

ditayangkan ulang oleh dr.erick supondha (hyperbaric&diving medicine consultant) dokter ahli hiperbarik dan kesehatan penyelaman jakarta indonesia 021 99070050