Perfluorocarbon-facilitated CNS
oxygen toxicity in rats: Reversal by edaravone.
Abstract/OtherAbstract:
Perfluorocarbon
(PFC) has been hypothesized to potentially increase the risk of central nervous
system oxygen toxicity (CNS-OT) under hyperbaric oxygen (HBO) conditions.
However, little is known about the effects, mechanism and prevention of
PFC-facilitated CNS-OT. A rat model of CNS-OT was used to evaluate the effects
of intravenously-administered PFC emulsion. The electroencephalogram (EEG) was
recorded during treatment with HBO(2) at 6.0 ATA in the presence and absence of
PFC. Concentrations of malondialdehyde (MDA), nitric oxide (NO) and hydrogen
peroxide (H(2)O(2)) in the brain cortex and hippocampus were quantified.
Changes in the activities of superoxide dismutase (SOD), glutathione peroxidase
(GPx), catalase (CAT) and NO synthase (NOS) in the brain cortex and hippocampus
were also determined. Edaravone, a potent antioxidant, was used to prevent
PFC-facilitated CNS-OT. The results showed that after PFC administration, the
latency to first electrical discharge in EEG was significantly shortened; MDA,
H(2)O(2), NO levels and NOS activity increased; and SOD, GPx and CAT activities
decreased. Edaravone effectively protected against CNS-OT and the adverse
effects of PFC. The results clearly demonstrate that PFC administered before
HBO(2) would promote the occurrence of CNS-OT, and edaravone could serve as a
promising chemoprophylactic agent to prevent CNS-OT.
Authors:
Shulin Liu; Runping Li; Xiaoxiao Ni;
Zhiyu Cai; Rongjia Zhang; Xuejun Sun; Raymond M Quock; Weigang Xu
Publication Detail:
Type: JOURNAL ARTICLE
Date: 2012-7-7
Journal Detail:
Title: Brain research
Volume: - ISSN: 1872-6240
ISO Abbreviation: - Publication
Date: 2012 Jul
Date Detail:
Created Date: 2012-7-11
Completed Date: - Revised
Date: -
Medline Journal Info:
Nlm Unique ID: 0045503
Medline TA: Brain Res Country:
-
Other Details:
Languages: ENG
Pagination: - Citation
Subset: -
Copyright Information:
Copyright © 2012. Published by
Elsevier B.V.
Affiliation:
Department
of Diving Medicine, the Second Military Medical University, Shanghai 200433, P.
R. China.
Ditayangkan
ulang olh dr.Erick Supondha (Hyperbaric&Diving Medicine Consultant) Jakarta
Indonesia, hyperbaric&diving medicine hotline 021 99070050
www.indodivinghealth.com
